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Imanib 400mg Tablet

prescription

Salt Composition

IMATINIB

Manufacturer

INTAS PHARMACEUTICALS LTD

Origin of Medicine

India

₹900.00

Inclusive of all taxes

Save ₹ 1232.45 (58%)
MRP:₹2132.45

₹900.00

    MRP:₹2132.45
Save ₹ 1232.45 (58%)
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Overview & Usage

Overview

Imanib 400 mg Tablet is a prescription medicine mainly used to treat certain types of cancers such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It contains Imatinib Mesylate, a targeted therapy that works by blocking specific proteins that help cancer cells grow, thereby slowing or stopping the disease.

This medicine targets abnormal enzymes like BCR-ABL in CML and c-KIT in GIST, preventing cancer cells from multiplying while allowing healthy cells to function normally. Because of its targeted action, Imanib is often better tolerated than standard chemotherapy, but it still requires regular monitoring by a doctor.

Imanib 400 mg is usually taken once daily with food and water to reduce stomach irritation. Common side effects may include nausea, diarrhea, muscle cramps, fatigue, or swelling. Though rare, serious issues like liver problems or low blood counts may occur, so it’s important to follow your doctor’s advice and report any unusual symptoms promptly.


Usage

  • 1. Chronic Myeloid Leukemia (CML):
  • Used to treat a type of blood cancer that affects white blood cells.

  • 2. Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL):
  • Used in the treatment of a specific type of fast-growing blood cancer.

  • 3. Gastrointestinal Stromal Tumors (GIST):
  • Used to treat a rare type of cancer in the digestive tract.

  • 4. Myelodysplastic/Myeloproliferative Diseases (MDS/MPD):
  • Used in conditions involving abnormal blood cell production.

  • 5. Systemic Mastocytosis :
  • Used to treat excessive production of mast cells in the body.

  • 6. Hypereosinophilic Syndrome and/or Chronic Eosinophilic Leukemia (HES/CEL):
  • Used in managing disorders with high levels of eosinophils, a type of white blood cell.

  • 7. Dermatofibrosarcoma Protuberans (DFSP):
  • Used for treating a rare type of skin cancer.

    Pharmacological Effects

    Imanib 400 mg Tablet contains Imatinib Mesylate, which is a tyrosine kinase inhibitor. It works by specifically targeting and blocking certain abnormal proteins (tyrosine kinases) that are responsible for the uncontrolled growth of cancer cells.

    In Chronic Myeloid Leukemia (CML), Imatinib inhibits the activity of the BCR-ABL fusion protein, a defective enzyme formed by a genetic mutation called the Philadelphia chromosome. This protein continuously signals white blood cells to grow and divide uncontrollably. By blocking BCR-ABL, Imanib stops this abnormal cell growth.

    In Gastrointestinal Stromal Tumors (GIST), Imanib blocks the c-KIT (CD117) tyrosine kinase, which is often overactive in these tumors. This helps to stop tumor growth and may even shrink the tumor.


    Side Effects

    Side Effects of Imanib 400 mg Tablet

    Serious Side Effects (Seek immediate medical attention):

    • Liver problems (signs include yellowing of skin or eyes, dark urine, stomach pain)
    • Low blood cell counts (may cause infections, bleeding, or anemia)
    • Fluid retention in lungs or heart
    • Chest pain or shortness of breath
    • Severe allergic reactions (rash, itching, or peeling skin)
    • Unusual bruising or bleeding

    Common Side Effects (Usually mild and temporary):

    • Tiredness or fatigue
    • Nausea or vomiting
    • Headache
    • Muscle cramps or joint pain
    • Diarrhea
    • Swelling around the eyes or ankles
    • Skin rash or itching
    • Loss of appetite

    Dosage

  • General Dosage Instructions:
  • Take the tablet at the same time every day

    Do not skip or double doses

    Always follow the doctor’s instructions for dose adjustments or duration of treatment


    Safety Advice For Imanib 400 mg Tablet

    Breast Feeding

    Breast Feeding

    Unsafe

    Not recommended unless advised by a doctor. It is unknown if the drug passes into breast milk and could harm the baby.

    Breast Feeding

    Alcohol

    Consult Your Doctor

    Avoid alcohol while taking Imashil, as it may increase the risk of liver damage.

    Breast Feeding

    Liver

    Consult Your Doctor

    Limit or avoid alcohol while taking this medicine, as it may increase the risk of liver damage or side effects.

    Breast Feeding

    Driving

    Unsafe

    Imanib may cause dizziness or fatigue in some individuals. Avoid driving or operating heavy machinery if you feel unwell.

    Breast Feeding

    Pregnancy

    unSafe

    Imanib is not recommended during pregnancy unless advised by a doctor. Use effective contraception during treatment

    Storage Advice

  • Store at room temperature between 20°C to 25°
  • Keep out of reach of children and pets
  • Keep the container tightly closed when not in use.
  • Keep the tablets in the original packaging to protect them from moisture and light.

  • FAQs about Imanib 400 mg Tablet

    Q1. What is Imanib 400 mg Tablet used for?

    Imanib 400 mg Tablet is primarily used to treat certain types of cancer, most notably Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). These are cancers that affect the blood and digestive tract respectively. Additionally, it may be prescribed for other rare cancers such as Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL), Hypereosinophilic Syndrome (HES), Systemic Mastocytosis, and Dermatofibrosarcoma Protuberans (DFSP).

    Q2. How should I take Imanib 400 mg Tablet?

    Imanib should be taken once daily with a meal and a full glass of water to help prevent stomach upset. Swallow the tablet whole—do not crush, chew, or break it. Take the medication at the same time each day for best results. Always follow the dosage and instructions given by your doctor, as the amount can vary depending on your specific condition.

    Q3. Can I stop taking Imanib if I feel better?

    No, you should not stop taking Imanib without medical advice, even if you start feeling better. Cancer treatments like Imanib work best when taken consistently over the prescribed period. Stopping early can lead to a return or worsening of the disease, so it’s important to complete the full course unless your doctor advises otherwise.

    Q4. What should I do if I miss a dose?

    If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects.

    Q5. What are the common side effects of Imashil?

    Common side effects of Imanib include nausea, vomiting, diarrhea, abdominal discomfort, fatigue, muscle cramps, and swelling (especially around the eyes or ankles). Some patients may also experience headaches or skin rashes. More serious side effects, though less common, include low blood cell counts, which can increase the risk of infection, bleeding, or anemia, as well as liver problems. If you experience any unusual or severe symptoms, contact your doctor immediately.

    Q6. Can I take Imanib during pregnancy or breastfeeding?

    Imanib is not recommended during pregnancy or breastfeeding as it may harm the unborn baby or nursing infant. Women of childbearing age should use effective contraception while taking this medicine and for a period after stopping it. If you are planning to become pregnant or discover that you are pregnant during treatment, inform your doctor right away.

    Q7. Is regular monitoring needed during treatment?

    Yes, regular medical check-ups and blood tests are essential during Imanib treatment. Your doctor will monitor your blood counts, liver and kidney function, and response to the medication to ensure it is working effectively and to detect any potential side effects early.

    Q8. Can I drink alcohol while taking Imashil?

    It is advisable to limit or avoid alcohol while taking Imashil. Alcohol can put extra strain on the liver and may increase the risk of liver-related side effects. Always speak with your doctor before consuming alcohol during your treatment.

    Key Fact Box

    Active ingredient Imatinib mesylate
    Pharmacologic class Tyrosine Kinase Inhibitor (TKI)
    Medication category ANTI NEOPLASTICS
    Dosage forms Tablet

    DOSAGE

    Frequently Asked Questions

    Azadine 100mg Injection contains Azacitidine which belongs to the group of medicines called Anticancer agents. It is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Azadine 100mg Injection is typically used in adults who cannot undergo stem cell transplantation. It may be also used to treat other conditions, as determined by the doctor.

    Azadine Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

    You must inform your doctor before taking any vaccination while on treatment with this medicine. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

    Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.

    MEDICINAL USE OF AZADINE 100MG INJECTION

    Azadine 100mg Injection is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    It is used to treat:

    • All sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow)
    • Chronic myelomonocytic leukemia (CMML; blood cancer of monocytes)
    • Acute myeloid leukemia (AML; blood cancer of WBC)
    SIDE EFFECTS OF AZADINE 100MG INJECTION

    Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

    • Low RBC count causing anemia, tiredness and pale skin
    • Increased infections, lung infections (pneumonia), fever and chills
    • Increased bleeding tendency due to low blood platelet counts
    • Nausea, vomiting
    • Diarrhea, constipation, loss of appetite, stomach pain
    • Tiredness, weakness
    • Injection site reactions (such as pain, redness and swelling or lump formation)
    • Joint pain, muscle pain, skin rashes with redness and itching
    • Sore nose and throat, cold sores, sinnusitis
    • Headache, dizziness
    • Trouble sleeping (insomnia)
    • Nosebleeds, bleeding gums
    • Weight loss
    • Urinary tract infections
    • Ulcers of mouth or tongue
    • High or low blood pressure
    • Anxiety, confusion
    • Hair loss, dehydration
    • Oral fungal infection
    • Sleepiness
    • Fluid around the lungs or heart
    DOSAGE OF AZADINE 100MG INJECTION
    • The dose of Azacitidine is determined by the patient's height, weight, and general condition. It is given under the skin of your thigh, stomach, or upper arm.
    • Minimum of 4 to 6 cycles; may continue treatment if the patient continues to benefit.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of a missed dose is very low.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

    Ques 1: What is the use of AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Ques 2: How does AZADINE 100MG INJECTION works?

    Ans :AZADINE 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    Ques 3: Can I take AZADINE 100MG INJECTION during breastfeeding?

    Ans :No. AZADINE 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.

    Ques 4: Can AZADINE 100MG INJECTION increase the risk of infections?

    Ans :AZADINE 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving AZADINE 100MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.

    Ques 5: Can the use of AZADINE 100MG INJECTION make me feel tired?

    Ans :Yes. AZADINE 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anemic. Consult your doctor if you experience tiredness after receiving AZADINE 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.

    Ques 6: Can I drive a car after receiving AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by AZADINE 100MG INJECTION.

    Ques 7: How AZADINE 100MG INJECTION is administered?

    Ans :AZADINE 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of thighs, arms or abdomen.

    Ques 8: How to control nausea caused due to AZADINE 100MG INJECTION?

    Ans :Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with AZADINE 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

    Overview

    Imanib 400 mg Tablet is a prescription medicine mainly used to treat certain types of cancers such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It contains Imatinib Mesylate, a targeted therapy that works by blocking specific proteins that help cancer cells grow, thereby slowing or stopping the disease.

    This medicine targets abnormal enzymes like BCR-ABL in CML and c-KIT in GIST, preventing cancer cells from multiplying while allowing healthy cells to function normally. Because of its targeted action, Imanib is often better tolerated than standard chemotherapy, but it still requires regular monitoring by a doctor.

    Imanib 400 mg is usually taken once daily with food and water to reduce stomach irritation. Common side effects may include nausea, diarrhea, muscle cramps, fatigue, or swelling. Though rare, serious issues like liver problems or low blood counts may occur, so it’s important to follow your doctor’s advice and report any unusual symptoms promptly.


    Usage

  • 1. Chronic Myeloid Leukemia (CML):
  • Used to treat a type of blood cancer that affects white blood cells.

  • 2. Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL):
  • Used in the treatment of a specific type of fast-growing blood cancer.

  • 3. Gastrointestinal Stromal Tumors (GIST):
  • Used to treat a rare type of cancer in the digestive tract.

  • 4. Myelodysplastic/Myeloproliferative Diseases (MDS/MPD):
  • Used in conditions involving abnormal blood cell production.

  • 5. Systemic Mastocytosis :
  • Used to treat excessive production of mast cells in the body.

  • 6. Hypereosinophilic Syndrome and/or Chronic Eosinophilic Leukemia (HES/CEL):
  • Used in managing disorders with high levels of eosinophils, a type of white blood cell.

  • 7. Dermatofibrosarcoma Protuberans (DFSP):
  • Used for treating a rare type of skin cancer.

    Pharmacological Effects

    Imanib 400 mg Tablet contains Imatinib Mesylate, which is a tyrosine kinase inhibitor. It works by specifically targeting and blocking certain abnormal proteins (tyrosine kinases) that are responsible for the uncontrolled growth of cancer cells.

    In Chronic Myeloid Leukemia (CML), Imatinib inhibits the activity of the BCR-ABL fusion protein, a defective enzyme formed by a genetic mutation called the Philadelphia chromosome. This protein continuously signals white blood cells to grow and divide uncontrollably. By blocking BCR-ABL, Imanib stops this abnormal cell growth.

    In Gastrointestinal Stromal Tumors (GIST), Imanib blocks the c-KIT (CD117) tyrosine kinase, which is often overactive in these tumors. This helps to stop tumor growth and may even shrink the tumor.


    Side Effects

    Side Effects of Imanib 400 mg Tablet

    Serious Side Effects (Seek immediate medical attention):

    • Liver problems (signs include yellowing of skin or eyes, dark urine, stomach pain)
    • Low blood cell counts (may cause infections, bleeding, or anemia)
    • Fluid retention in lungs or heart
    • Chest pain or shortness of breath
    • Severe allergic reactions (rash, itching, or peeling skin)
    • Unusual bruising or bleeding

    Common Side Effects (Usually mild and temporary):

    • Tiredness or fatigue
    • Nausea or vomiting
    • Headache
    • Muscle cramps or joint pain
    • Diarrhea
    • Swelling around the eyes or ankles
    • Skin rash or itching
    • Loss of appetite

    Dosage

  • General Dosage Instructions:
  • Take the tablet at the same time every day

    Do not skip or double doses

    Always follow the doctor’s instructions for dose adjustments or duration of treatment


    Safety Advice For Imanib 400 mg Tablet

    Breast Feeding

    Breast Feeding

    Unsafe

    Not recommended unless advised by a doctor. It is unknown if the drug passes into breast milk and could harm the baby.

    Breast Feeding

    Alcohol

    Consult Your Doctor

    Avoid alcohol while taking Imashil, as it may increase the risk of liver damage.

    Breast Feeding

    Liver

    Consult Your Doctor

    Limit or avoid alcohol while taking this medicine, as it may increase the risk of liver damage or side effects.

    Breast Feeding

    Driving

    Unsafe

    Imanib may cause dizziness or fatigue in some individuals. Avoid driving or operating heavy machinery if you feel unwell.

    Breast Feeding

    Pregnancy

    unSafe

    Imanib is not recommended during pregnancy unless advised by a doctor. Use effective contraception during treatment

    Storage Advice

  • Store at room temperature between 20°C to 25°
  • Keep out of reach of children and pets
  • Keep the container tightly closed when not in use.
  • Keep the tablets in the original packaging to protect them from moisture and light.

  • FAQs about Imanib 400 mg Tablet

    Q1. What is Imanib 400 mg Tablet used for?

    Imanib 400 mg Tablet is primarily used to treat certain types of cancer, most notably Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). These are cancers that affect the blood and digestive tract respectively. Additionally, it may be prescribed for other rare cancers such as Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL), Hypereosinophilic Syndrome (HES), Systemic Mastocytosis, and Dermatofibrosarcoma Protuberans (DFSP).

    Q2. How should I take Imanib 400 mg Tablet?

    Imanib should be taken once daily with a meal and a full glass of water to help prevent stomach upset. Swallow the tablet whole—do not crush, chew, or break it. Take the medication at the same time each day for best results. Always follow the dosage and instructions given by your doctor, as the amount can vary depending on your specific condition.

    Q3. Can I stop taking Imanib if I feel better?

    No, you should not stop taking Imanib without medical advice, even if you start feeling better. Cancer treatments like Imanib work best when taken consistently over the prescribed period. Stopping early can lead to a return or worsening of the disease, so it’s important to complete the full course unless your doctor advises otherwise.

    Q4. What should I do if I miss a dose?

    If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects.

    Q5. What are the common side effects of Imashil?

    Common side effects of Imanib include nausea, vomiting, diarrhea, abdominal discomfort, fatigue, muscle cramps, and swelling (especially around the eyes or ankles). Some patients may also experience headaches or skin rashes. More serious side effects, though less common, include low blood cell counts, which can increase the risk of infection, bleeding, or anemia, as well as liver problems. If you experience any unusual or severe symptoms, contact your doctor immediately.

    Q6. Can I take Imanib during pregnancy or breastfeeding?

    Imanib is not recommended during pregnancy or breastfeeding as it may harm the unborn baby or nursing infant. Women of childbearing age should use effective contraception while taking this medicine and for a period after stopping it. If you are planning to become pregnant or discover that you are pregnant during treatment, inform your doctor right away.

    Q7. Is regular monitoring needed during treatment?

    Yes, regular medical check-ups and blood tests are essential during Imanib treatment. Your doctor will monitor your blood counts, liver and kidney function, and response to the medication to ensure it is working effectively and to detect any potential side effects early.

    Q8. Can I drink alcohol while taking Imashil?

    It is advisable to limit or avoid alcohol while taking Imashil. Alcohol can put extra strain on the liver and may increase the risk of liver-related side effects. Always speak with your doctor before consuming alcohol during your treatment.

    Key Fact Box

    Active ingredient Imatinib mesylate
    Pharmacologic class Tyrosine Kinase Inhibitor (TKI)
    Medication category ANTI NEOPLASTICS
    Dosage forms Tablet
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