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Bevatas 100mg Injection

prescription

Salt Composition

BEVACIZUMAB

Manufacturer

INTAS PHARMACEUTICALS LTD

Origin of Medicine

India

₹4163.00

Inclusive of all taxes

Save ₹ 10704.5 (72%)
MRP:₹14867.50

₹4163.00

    MRP:₹14867.50
Save ₹ 10704.5 (72%)
1 Vial(s) Of 4ml

1 Vial(s) Of 4ml

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Overview & Usage

Overview

Bevatas 100mg Injection is a targeted cancer therapy used to treat advanced cancers. It works by blocking a protein called VEGF-A, which helps tumors grow new blood vessels. By stopping this process, Bevatas cuts off the tumor’s blood supply, slowing its growth and spread.

Bevatas 100mg Injection is administered by a healthcare professional as an intravenous (IV) infusion. It is typically given once every 2 to 3 weeks, with the dose adjusted according to your body weight.

Inform your medical team immediately if you experience dizziness, nausea, light-headedness, sweating, headache, shortness of breath, or chest pain during the infusion.

Regular medical tests may be required to monitor your response to treatment. Depending on the results, your treatment schedule may be adjusted or delayed.

Bevatas 100mg Injection is not recommended for children and teenagers under 18 years, as its safety and effectiveness have not been confirmed for this age group. In elderly patients (65 years and above), it should be used with caution and only under a doctor’s supervision.


Usage

Cervical cancer (used with paclitaxel + cisplatin/topotecan)

Colorectal cancer (used with fluorouracil, irinotecan, or oxaliplatin)

Glioblastoma (a brain cancer that has returned)

Liver cancer (used with atezolizumab)

Non-small cell lung cancer (used with carboplatin + paclitaxel)

Kidney cancer (renal cell carcinoma) (used with interferon alpha)

Pharmacological Effects

Bevacizumab is a monoclonal antibody that works by blocking vascular endothelial growth factor (VEGF). VEGF is a protein that helps cancer cells form new blood vessels (a process called angiogenesis), which tumors need to grow and spread.

By inhibiting VEGF, Bevacizumab slows or stops the growth of blood vessels that supply tumors, thereby starving the tumor of nutrients and oxygen. This helps slow tumor growth, shrink tumors, and enhance the effectiveness of other cancer treatments.


Side Effects

Side Effects of Bevatas 100mg Injection

Like all medications, Bevatas 100mg Injection may cause side effects. However, not everyone will experience them.

Serious Side Effects (Seek immediate medical attention):

  • Allergic reactions: hives, trouble breathing, or swelling of the face or throat seek emergency help. (TB)
  • During infusion: dizziness, nausea, sweating, headache, chest tightness, or breathing issues tell your healthcare provider immediately.
  • Rare brain disorder: extreme tiredness, confusion, vision changes, or seizures call your doctor right away.
  • Bleeding: easy bruising, severe stomach pain, blood in stools or vomit, or signs of brain bleeding like slurred speech or sudden weakness.
  • Liver problems (yellowing of skin or eyes, dark urine)
  • Organ damage: stomach or intestinal tears, slow wound healing, infections, or abnormal openings in organs.
  • Other issues: missed periods, kidney or heart problems, blood clots, or low white blood cell counts.

Common Side Effects (Usually mild and temporary):

  • High blood pressure : Your blood pressure may rise during treatment, so regular monitoring is important.
  • Headache: Mild to moderate headaches can occur but are usually temporary.
  • Back pain: Some patients may feel discomfort or aching in the lower back.
  • Dry or watery eyes: Your eyes might feel irritated, either too dry or excessively watery.
  • Dry or flaky skin: Skin may become drier than usual or start to flake keeping moisturized can help.:
  • Runny or stuffy nose: You might notice nasal congestion or a constantly runny nose.
  • Sneezing : Occasional sneezing is also a possible effect.

Dosage

For colorectal cancer, bevacizumab is given through a drip (IV infusion) along with chemotherapy. The amount depends on the type of chemotherapy used—either every 2 weeks at a lower dose or a higher dose. If the cancer comes back or gets worse after the first treatment, it can still be given every 2 or 3 weeks at adjusted doses.

In lung cancer (non-small cell type), the usual dose is given once every 3 weeks together with other chemotherapy medicines like carboplatin and paclitaxel. The treatment is continued as long as it helps and the side effects are manageable.

For brain cancer (glioblastoma), the medicine is usually given once every 2 weeks through an IV infusion. Treatment continues until the cancer worsens or the side effects become too difficult to handle.


Safety Advice For Bevatas 100mg Injection

Breast Feeding

Breast Feeding

Safe

Do not breastfeed while taking Bevatas 100mg Injection, and for at least 6 months after the treatment. The medicine can affect your baby’s growth.

Breast Feeding

Alcohol

Consult Your Doctor

It is not clear if drinking alcohol is safe during this treatment. Please check with your doctor before consuming alcohol.

Breast Feeding

Lungs

Consult Your Doctor

Tell your doctor if you have any lung conditions before beginning this treatment.

Breast Feeding

Driving

Unsafe

Avoid driving or operating machines while on this medicine, as it can cause dizziness or sleepiness.

Breast Feeding

Pregnancy

Unsafe

Do not use Bevatas 100mg Injection if you are pregnant or planning to become pregnant. This medicine can harm your unborn baby and affect the formation of blood vessels.

Storage Advice

  • Store in a refrigerator (2 - 8°C)
  • Do not freeze
  • Keep out of reach of children and pets

  • FAQs about Bevatas 100mg Injection

    Q1. How does Bevatas 100 Solution for Infusion work differently from Chemotherapy?

    Unlike traditional chemotherapy, which targets and kills fast-growing cells (including cancer cells), Bevatas 100 works by blocking the formation of new blood vessels that supply nutrients to tumors. By cutting off this blood supply, it helps shrink the tumor or stop it from growing further.

    Q2. Do the side effects of Bevatas 100mg Injection last for a long time?

    The side effects of Bevatas 100mg Injection generally last as long as the drug remains in your body. Research shows that the medication can stay in the system for up to 4 months after the final dose. However, the intensity and duration of side effects may vary from person to person.

    Q3. What other medicines can interact with Bevacizumab?

    Be sure to inform your doctor about all the cancer treatments you're currently receiving. Bevacizumab may interact with other medicines, including prescription drugs, over-the-counter products, vitamins, or herbal supplements. Always let your doctor know about everything you're taking to avoid any unwanted effects.

    Q4. Can Bevacizumab interact with food or drinks?

    There are no known food or drink interactions with Bevacizumab. However, it's unclear how alcohol might affect the medicine. Since both Bevacizumab and alcohol can raise the risk of bleeding, it's safer to limit alcohol intake while on this treatment.

    Q5. What should I do if I miss a dose of Bevacizumab?

    Bevacizumab is typically given by a healthcare provider at a clinic or hospital. They will manage your treatment schedule.If you miss an appointment, contact your doctor or clinic right away to reschedule your dose.

    Q6. Are there any drug interactions with Bevacizumab?

    Yes, Bevacizumab can interact with certain medicines, including paclitaxel and carboplatin. To avoid possible interactions, always inform your doctor about all the medications you are taking.

    Key Fact Box

    Active ingredient Bevacizumab
    Pharmacologic class Monoclonal antibody (anti-VEGF)
    Medication category ANTI NEOPLASTICS
    Dosage forms Injection

    References

  • https://en.wikipedia.org/wiki/Bevacizumab
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC7964163/
  • https://www.sciencedirect.com/topics/pharmacology-toxicology-and-     pharmaceutical-science/bevacizumab
  • https://www.ncbi.nlm.nih.gov/books/NBK482126/
  • DOSAGE

    Frequently Asked Questions

    Azadine 100mg Injection contains Azacitidine which belongs to the group of medicines called Anticancer agents. It is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Azadine 100mg Injection is typically used in adults who cannot undergo stem cell transplantation. It may be also used to treat other conditions, as determined by the doctor.

    Azadine Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

    You must inform your doctor before taking any vaccination while on treatment with this medicine. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

    Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.

    MEDICINAL USE OF AZADINE 100MG INJECTION

    Azadine 100mg Injection is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    It is used to treat:

    • All sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow)
    • Chronic myelomonocytic leukemia (CMML; blood cancer of monocytes)
    • Acute myeloid leukemia (AML; blood cancer of WBC)
    SIDE EFFECTS OF AZADINE 100MG INJECTION

    Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

    • Low RBC count causing anemia, tiredness and pale skin
    • Increased infections, lung infections (pneumonia), fever and chills
    • Increased bleeding tendency due to low blood platelet counts
    • Nausea, vomiting
    • Diarrhea, constipation, loss of appetite, stomach pain
    • Tiredness, weakness
    • Injection site reactions (such as pain, redness and swelling or lump formation)
    • Joint pain, muscle pain, skin rashes with redness and itching
    • Sore nose and throat, cold sores, sinnusitis
    • Headache, dizziness
    • Trouble sleeping (insomnia)
    • Nosebleeds, bleeding gums
    • Weight loss
    • Urinary tract infections
    • Ulcers of mouth or tongue
    • High or low blood pressure
    • Anxiety, confusion
    • Hair loss, dehydration
    • Oral fungal infection
    • Sleepiness
    • Fluid around the lungs or heart
    DOSAGE OF AZADINE 100MG INJECTION
    • The dose of Azacitidine is determined by the patient's height, weight, and general condition. It is given under the skin of your thigh, stomach, or upper arm.
    • Minimum of 4 to 6 cycles; may continue treatment if the patient continues to benefit.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of a missed dose is very low.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

    Ques 1: What is the use of AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Ques 2: How does AZADINE 100MG INJECTION works?

    Ans :AZADINE 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    Ques 3: Can I take AZADINE 100MG INJECTION during breastfeeding?

    Ans :No. AZADINE 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.

    Ques 4: Can AZADINE 100MG INJECTION increase the risk of infections?

    Ans :AZADINE 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving AZADINE 100MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.

    Ques 5: Can the use of AZADINE 100MG INJECTION make me feel tired?

    Ans :Yes. AZADINE 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anemic. Consult your doctor if you experience tiredness after receiving AZADINE 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.

    Ques 6: Can I drive a car after receiving AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by AZADINE 100MG INJECTION.

    Ques 7: How AZADINE 100MG INJECTION is administered?

    Ans :AZADINE 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of thighs, arms or abdomen.

    Ques 8: How to control nausea caused due to AZADINE 100MG INJECTION?

    Ans :Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with AZADINE 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

    Overview

    Bevatas 100mg Injection is a targeted cancer therapy used to treat advanced cancers. It works by blocking a protein called VEGF-A, which helps tumors grow new blood vessels. By stopping this process, Bevatas cuts off the tumor’s blood supply, slowing its growth and spread.

    Bevatas 100mg Injection is administered by a healthcare professional as an intravenous (IV) infusion. It is typically given once every 2 to 3 weeks, with the dose adjusted according to your body weight.

    Inform your medical team immediately if you experience dizziness, nausea, light-headedness, sweating, headache, shortness of breath, or chest pain during the infusion.

    Regular medical tests may be required to monitor your response to treatment. Depending on the results, your treatment schedule may be adjusted or delayed.

    Bevatas 100mg Injection is not recommended for children and teenagers under 18 years, as its safety and effectiveness have not been confirmed for this age group. In elderly patients (65 years and above), it should be used with caution and only under a doctor’s supervision.


    Usage

    Cervical cancer (used with paclitaxel + cisplatin/topotecan)

    Colorectal cancer (used with fluorouracil, irinotecan, or oxaliplatin)

    Glioblastoma (a brain cancer that has returned)

    Liver cancer (used with atezolizumab)

    Non-small cell lung cancer (used with carboplatin + paclitaxel)

    Kidney cancer (renal cell carcinoma) (used with interferon alpha)

    Pharmacological Effects

    Bevacizumab is a monoclonal antibody that works by blocking vascular endothelial growth factor (VEGF). VEGF is a protein that helps cancer cells form new blood vessels (a process called angiogenesis), which tumors need to grow and spread.

    By inhibiting VEGF, Bevacizumab slows or stops the growth of blood vessels that supply tumors, thereby starving the tumor of nutrients and oxygen. This helps slow tumor growth, shrink tumors, and enhance the effectiveness of other cancer treatments.


    Side Effects

    Side Effects of Bevatas 100mg Injection

    Like all medications, Bevatas 100mg Injection may cause side effects. However, not everyone will experience them.

    Serious Side Effects (Seek immediate medical attention):

    • Allergic reactions: hives, trouble breathing, or swelling of the face or throat seek emergency help. (TB)
    • During infusion: dizziness, nausea, sweating, headache, chest tightness, or breathing issues tell your healthcare provider immediately.
    • Rare brain disorder: extreme tiredness, confusion, vision changes, or seizures call your doctor right away.
    • Bleeding: easy bruising, severe stomach pain, blood in stools or vomit, or signs of brain bleeding like slurred speech or sudden weakness.
    • Liver problems (yellowing of skin or eyes, dark urine)
    • Organ damage: stomach or intestinal tears, slow wound healing, infections, or abnormal openings in organs.
    • Other issues: missed periods, kidney or heart problems, blood clots, or low white blood cell counts.

    Common Side Effects (Usually mild and temporary):

    • High blood pressure : Your blood pressure may rise during treatment, so regular monitoring is important.
    • Headache: Mild to moderate headaches can occur but are usually temporary.
    • Back pain: Some patients may feel discomfort or aching in the lower back.
    • Dry or watery eyes: Your eyes might feel irritated, either too dry or excessively watery.
    • Dry or flaky skin: Skin may become drier than usual or start to flake keeping moisturized can help.:
    • Runny or stuffy nose: You might notice nasal congestion or a constantly runny nose.
    • Sneezing : Occasional sneezing is also a possible effect.

    Dosage

    For colorectal cancer, bevacizumab is given through a drip (IV infusion) along with chemotherapy. The amount depends on the type of chemotherapy used—either every 2 weeks at a lower dose or a higher dose. If the cancer comes back or gets worse after the first treatment, it can still be given every 2 or 3 weeks at adjusted doses.

    In lung cancer (non-small cell type), the usual dose is given once every 3 weeks together with other chemotherapy medicines like carboplatin and paclitaxel. The treatment is continued as long as it helps and the side effects are manageable.

    For brain cancer (glioblastoma), the medicine is usually given once every 2 weeks through an IV infusion. Treatment continues until the cancer worsens or the side effects become too difficult to handle.


    Safety Advice For Bevatas 100mg Injection

    Breast Feeding

    Breast Feeding

    Safe

    Do not breastfeed while taking Bevatas 100mg Injection, and for at least 6 months after the treatment. The medicine can affect your baby’s growth.

    Breast Feeding

    Alcohol

    Consult Your Doctor

    It is not clear if drinking alcohol is safe during this treatment. Please check with your doctor before consuming alcohol.

    Breast Feeding

    Lungs

    Consult Your Doctor

    Tell your doctor if you have any lung conditions before beginning this treatment.

    Breast Feeding

    Driving

    Unsafe

    Avoid driving or operating machines while on this medicine, as it can cause dizziness or sleepiness.

    Breast Feeding

    Pregnancy

    Unsafe

    Do not use Bevatas 100mg Injection if you are pregnant or planning to become pregnant. This medicine can harm your unborn baby and affect the formation of blood vessels.

    Storage Advice

  • Store in a refrigerator (2 - 8°C)
  • Do not freeze
  • Keep out of reach of children and pets

  • FAQs about Bevatas 100mg Injection

    Q1. How does Bevatas 100 Solution for Infusion work differently from Chemotherapy?

    Unlike traditional chemotherapy, which targets and kills fast-growing cells (including cancer cells), Bevatas 100 works by blocking the formation of new blood vessels that supply nutrients to tumors. By cutting off this blood supply, it helps shrink the tumor or stop it from growing further.

    Q2. Do the side effects of Bevatas 100mg Injection last for a long time?

    The side effects of Bevatas 100mg Injection generally last as long as the drug remains in your body. Research shows that the medication can stay in the system for up to 4 months after the final dose. However, the intensity and duration of side effects may vary from person to person.

    Q3. What other medicines can interact with Bevacizumab?

    Be sure to inform your doctor about all the cancer treatments you're currently receiving. Bevacizumab may interact with other medicines, including prescription drugs, over-the-counter products, vitamins, or herbal supplements. Always let your doctor know about everything you're taking to avoid any unwanted effects.

    Q4. Can Bevacizumab interact with food or drinks?

    There are no known food or drink interactions with Bevacizumab. However, it's unclear how alcohol might affect the medicine. Since both Bevacizumab and alcohol can raise the risk of bleeding, it's safer to limit alcohol intake while on this treatment.

    Q5. What should I do if I miss a dose of Bevacizumab?

    Bevacizumab is typically given by a healthcare provider at a clinic or hospital. They will manage your treatment schedule.If you miss an appointment, contact your doctor or clinic right away to reschedule your dose.

    Q6. Are there any drug interactions with Bevacizumab?

    Yes, Bevacizumab can interact with certain medicines, including paclitaxel and carboplatin. To avoid possible interactions, always inform your doctor about all the medications you are taking.

    Key Fact Box

    Active ingredient Bevacizumab
    Pharmacologic class Monoclonal antibody (anti-VEGF)
    Medication category ANTI NEOPLASTICS
    Dosage forms Injection

    References

  • https://en.wikipedia.org/wiki/Bevacizumab
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC7964163/
  • https://www.sciencedirect.com/topics/pharmacology-toxicology-and-     pharmaceutical-science/bevacizumab
  • https://www.ncbi.nlm.nih.gov/books/NBK482126/
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