Azadine 100mg Injection contains Azacitidine, an anticancer agent used in adults for the treatment of all sub-types of myelodysplastic syndromes (MDS), as well as specific types of blood cancers such as chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML). CMML is characterized by the excessive production of monocytes—a type of white blood cell—by the bone marrow, which can lead to symptoms like frequent infections, fever, fatigue, and increased bleeding or bruising. Similarly, AML involves the release of large numbers of immature white blood cells, resulting in comparable symptoms. Azadine is typically prescribed to patients who are not suitable candidates for stem cell transplantation.

Before starting treatment with Azadine, it is important to inform your doctor if you have any underlying health issues involving the lungs, liver, kidneys, or heart. This medicine is not recommended during pregnancy or breastfeeding. Men and women of reproductive age should use effective contraception throughout the treatment period. Men may also be advised to consider sperm preservation before initiating therapy.

Common side effects associated with Azadine 100mg Injection include an increased risk of bleeding or infections, fatigue, nausea, vomiting, diarrhea, constipation, loss of appetite, stomach pain, and general weakness. Some individuals may also experience pain, redness, or swelling at the injection site, sore throat, cold sores, ulcers in the mouth or on the tongue, headache, dizziness, trouble sleeping, weight loss, and hair loss. If any of these side effects become persistent or troublesome, it is important to consult your doctor.

Azadine 100mg Injection is used to treat all sub-types of myelodysplastic syndromes, a group of conditions where the bone marrow does not produce healthy blood cells.

It is used to treat CMML, a type of blood cancer in which the bone marrow produces too many monocytes, a type of white blood cell.

Azadine is also used in certain cases of AML, a cancer of the blood and bone marrow that leads to the overproduction of immature white blood cells.

This medicine is especially useful for adult patients with the above conditions who are not suitable candidates for stem cell transplantation.

Azacitidine is a chemotherapy drug that works in two main ways. At low doses, it blocks an enzyme called DNA methyltransferase, leading to DNA hypomethylation, which helps reactivate normal genes and slow cancer growth. At higher doses, it gets incorporated into RNA and DNA, disrupting their function and killing abnormal blood cells. It mainly targets rapidly dividing cancer cells in the bone marrow, while having less effect on normal, non-dividing cells.

Side Effects of Azadine 100mg Injection

Like all medications, Azadine 100mg Injection may cause side effects. However, not everyone will experience them.

Serious Side Effects (Seek immediate medical attention):

• Increased risk of infections (due to low white blood cells)
• Fever, chills, or persistent sore throat (signs of infection)
• Easy bruising or excessive bleeding (due to low platelet count)
• Severe allergic reactions – rash, itching, swelling, difficulty breathing (rare)
• Very low blood cell counts (anemia, neutropenia, thrombocytopenia)
• Signs of organ toxicity (e.g., yellowing of eyes/skin, dark urine – indicating liver issues)

Common Side Effects (Usually mild and temporary):

• Fatigue or tiredness
• Nausea and vomiting
• Loss of appetite
• Abdominal (stomach) pain
• General weakness
• Pain, redness, or swelling at the injection site
• Headache
• Dizziness
• Trouble sleeping (insomnia)
• Sore throat or cold sores
• Mouth or tongue ulcers
• Weight loss
• Hair loss

The dosage of Azadine (Azacitidine) is determined by a doctor based on the patient’s body surface area, medical condition, and response to treatment. It is administered by a healthcare professional either under the skin (subcutaneously) or into a vein (intravenously).

Breast Feeding

Unsafe

Azadine Injection is not safe while breastfeeding, as it may pass into breast milk and harm the baby.

Alcohol

Consult Your Doctor

You need to tell your physician if you have any liver disorders before starting Azadine 100mg Injection as it requires dosage adjustment for severe liver impairment.

Lungs

Unsafe

Talk to your doctor if you have any lung conditions before starting treatment with Azadine 100mg Injection.

Driving

Unsafe

Azadine may cause dizziness or fatigue. Avoid driving or using heavy machinery if you feel unwell.

Pregnancy

Unsafe

Azadine Injection should not be used during pregnancy as it may harm the baby. In very serious cases, your doctor might still give it if the benefits are greater than the risks. Always talk to your doctor first.

Azadine is used to treat certain types of blood and bone marrow cancers in adults, including myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML), and acute myeloid leukaemia (AML).

Azadine contains Azacitidine, which works by blocking abnormal DNA activity and killing rapidly growing cancer cells in the bone marrow. It helps restore normal blood cell production and slows disease progression.

Azadine is given by injection, either under the skin (subcutaneously) or into a vein (intravenously), usually once daily for 7 days in a 28-day treatment cycle. It must be administered by a healthcare professional.

Common side effects include fatigue, nausea, vomiting, diarrhea, constipation, appetite loss, injection site reactions, mouth ulcers, and low blood counts, which may lead to infections or bleeding.

No. Azadine is not recommended during pregnancy or breastfeeding. Effective birth control should be used during treatment. Men may consider sperm preservation before starting therapy.

Yes. Your doctor will monitor your blood counts, liver, and kidney function regularly to ensure the treatment is safe and effective.

You should inform your doctor about all the medicines you are taking. Some drugs may interact with Azadine, so medical supervision is important.

Treatment duration varies by individual. Most patients receive at least 6 cycles, but your doctor will decide based on how you respond to the treatment.

Azadine should only be administered by a healthcare provider, so any missed dose will be managed by your medical team. Do not try to take the medicine on your own.

If you feel dizzy, weak, or tired after the injection, avoid driving or using heavy machinery.