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Denoci 120mg Injection

prescription

Salt Composition

DENOSUMAB

Manufacturer

CIPLA LTD

Origin of Medicine

India

₹16000.00

Inclusive of all taxes

Save ₹ 13390.63 (46%)
MRP:₹29390.63

₹16000.00

    MRP:₹29390.63
Save ₹ 13390.63 (46%)
1 vial(s)

1 vial(s)

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Overview & Usage

Overview

Denoci 120 mg Injection is a prescription medication that contains denosumab 120 mg, a monoclonal antibody used to treat osteoporosis and other bone-related conditions. It is commonly prescribed to postmenopausal women and men who are at high risk of bone fractures due to weakened bones.

Denoci works by blocking a protein called RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand), which is involved in the breakdown of bone. By inhibiting this protein, Denoci helps to reduce bone loss, increase bone density, and strengthen bones. It is also used to prevent bone thinning in patients receiving certain cancer treatments.

Denoci 120 mg is administered as a subcutaneous injection once every six months by a healthcare professional, and calcium and vitamin D supplements are usually recommended during the course of treatment to support bone health.

Denoci 120 mg Injection may cause side effects like back, joint, or muscle pain, and pain in the arms or legs. Some people may have high cholesterol or urinary infections. Serious but less common effects include low blood calcium (hypocalcemia), infections, skin rashes, jaw bone issues (osteonecrosis), or rare thigh bone fractures. Inform your doctor about any unusual symptoms or if you have low calcium, kidney problems, or dental concerns. Taking calcium and vitamin D supplements and regular check-ups can help manage side effects.


Usage

1. Treats and prevents bone loss in various conditions.

2. Used for osteoporosis in postmenopausal women at high risk of fractures.

3. Helps men with osteoporosis who are at increased risk of bone fractures.

4. Prevents bone loss due to hormone-deprivation therapy in men with prostate cancer.

5. Reduces bone loss caused by aromatase inhibitor therapy in women with breast cancer

6.Helps increase bone mass in individuals at risk of fractures due to other medical conditions or treatments.

Pharmacological Effects

Denoci 120 mg Injection contains denosumab, a monoclonal antibody that works by targeting and inhibiting a protein called RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand). RANKL is essential for the formation, function, and survival of osteoclasts, the cells responsible for breaking down bone. By blocking RANKL, denosumab prevents the activation of osteoclasts, reducing bone resorption (breakdown) and helping to maintain or increase bone density. This mechanism helps strengthen bones and reduce the risk of fractures, particularly in people with osteoporosis or those undergoing cancer treatments that weaken bones.


Side Effects

Side Effects of Denoci 120 mg Injection

Like all medications, Denoci 120 mg Injection may cause side effects. However, not everyone will experience them.

Serious Side Effects (Seek immediate medical attention):

  • Low blood calcium levels (hypocalcemia) symptoms may include muscle cramps, numbness, or tingling
  • Serious allergic reactions (rash, swelling, breathing trouble)
  • Serious infections such as skin, abdominal, or urinary infections
  • Osteonecrosis of the jaw (jaw bone damage), especially after dental procedures
  • Atypical femur fractures (unusual thigh bone fractures)
  • It is important to inform your doctor about any unusual symptoms and to maintain adequate calcium and vitamin D intake during treatment.

Common Side Effects (Usually mild and temporary):

  • Urinary tract infections
  • High cholesterol levels
  • Pain in arms or legs
  • Back pain
  • Joint or back pain

Dosage

The recommended dosage of Denoci 120 mg Injection is one injection (120 mg) administered once every six months. It is given as a subcutaneous injection (under the skin) in the upper arm, upper thigh, or abdomen by a healthcare professional.

Patients are usually advised to take calcium (at least 1000 mg) and vitamin D (at least 400 IU) daily during treatment to help maintain healthy calcium levels and support bone health. Regular follow-up and blood tests may be needed to monitor calcium levels and bone condition.


Safety Advice for Denoci 120 mg Injection

Breast Feeding

Breast Feeding

Unsafe

Avoid using this injection while breastfeeding unless advised by your doctor.

Breast Feeding

Alcohol

Consult Your Doctor

It is advisable to limit alcohol intake, as excessive consumption can weaken bones and increase the risk of side effects.

Breast Feeding

Lungs

Safe

Use Denoci 120 mg Injection with caution if you have existing lung problems, and immediately inform your doctor if you experience cough, shortness of breath, or chest discomfort during treatment.

Breast Feeding

Driving

Unsafe

Denoci is unlikely to affect your ability to drive or use machines. However, if you feel dizzy or tired, avoid such activities.

Breast Feeding

Pregnancy

Unsafe

Denoci is not recommended for use during pregnancy. Inform your doctor if you are pregnant or planning to conceive.

Storage Advice

  • Store in a refrigerator (2 - 8°C)
  • Do not freeze
  • Keep out of reach of children and pets

  • FAQs about Denoci 120 mg Injection

    Q1. What is Denoci 120 mg Injection used for?

    Denoci is used to treat osteoporosis and bone loss in postmenopausal women and men at high risk of fractures. It is also used in patients receiving hormone therapy for prostate or breast cancer.

    Q2. How is Denoci 120 mg Injection given?

    Denoci is given as a subcutaneous injection (under the skin) once every six months by a healthcare professional.

    Q3. What should I do if I miss a dose?

    If you miss a dose, get it as soon as possible. Future doses should be scheduled every six months from the last injection date.

    Q4. Are there any side effects of Denoci ?

    Yes. Common side effects include back pain, joint pain, high cholesterol, and urinary tract infections. Serious side effects can include low blood calcium levels, infections, and rare jaw or thigh bone problems.

    Q5. Can I take Denoci if I have kidney problems?

    Use with caution in people with kidney issues, as the risk of low calcium levels increases. Your doctor may recommend calcium and vitamin D supplements and regular monitoring.

    Q6. Can I use Denoci during pregnancy or breastfeeding?

    No, Denoci is not recommended during pregnancy or breastfeeding. Inform your doctor if you are pregnant or planning to become pregnant.

    Key Fact Box

    Active ingredient Denosumab
    Pharmacologic class Monoclonal antibody
    Medication category Antiresorptive agent
    Dosage forms Injection

    DOSAGE

    Frequently Asked Questions

    Azadine 100mg Injection contains Azacitidine which belongs to the group of medicines called Anticancer agents. It is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Azadine 100mg Injection is typically used in adults who cannot undergo stem cell transplantation. It may be also used to treat other conditions, as determined by the doctor.

    Azadine Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

    You must inform your doctor before taking any vaccination while on treatment with this medicine. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

    Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.

    MEDICINAL USE OF AZADINE 100MG INJECTION

    Azadine 100mg Injection is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    It is used to treat:

    • All sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow)
    • Chronic myelomonocytic leukemia (CMML; blood cancer of monocytes)
    • Acute myeloid leukemia (AML; blood cancer of WBC)
    SIDE EFFECTS OF AZADINE 100MG INJECTION

    Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

    • Low RBC count causing anemia, tiredness and pale skin
    • Increased infections, lung infections (pneumonia), fever and chills
    • Increased bleeding tendency due to low blood platelet counts
    • Nausea, vomiting
    • Diarrhea, constipation, loss of appetite, stomach pain
    • Tiredness, weakness
    • Injection site reactions (such as pain, redness and swelling or lump formation)
    • Joint pain, muscle pain, skin rashes with redness and itching
    • Sore nose and throat, cold sores, sinnusitis
    • Headache, dizziness
    • Trouble sleeping (insomnia)
    • Nosebleeds, bleeding gums
    • Weight loss
    • Urinary tract infections
    • Ulcers of mouth or tongue
    • High or low blood pressure
    • Anxiety, confusion
    • Hair loss, dehydration
    • Oral fungal infection
    • Sleepiness
    • Fluid around the lungs or heart
    DOSAGE OF AZADINE 100MG INJECTION
    • The dose of Azacitidine is determined by the patient's height, weight, and general condition. It is given under the skin of your thigh, stomach, or upper arm.
    • Minimum of 4 to 6 cycles; may continue treatment if the patient continues to benefit.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of a missed dose is very low.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

    Ques 1: What is the use of AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Ques 2: How does AZADINE 100MG INJECTION works?

    Ans :AZADINE 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    Ques 3: Can I take AZADINE 100MG INJECTION during breastfeeding?

    Ans :No. AZADINE 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.

    Ques 4: Can AZADINE 100MG INJECTION increase the risk of infections?

    Ans :AZADINE 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving AZADINE 100MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.

    Ques 5: Can the use of AZADINE 100MG INJECTION make me feel tired?

    Ans :Yes. AZADINE 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anemic. Consult your doctor if you experience tiredness after receiving AZADINE 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.

    Ques 6: Can I drive a car after receiving AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by AZADINE 100MG INJECTION.

    Ques 7: How AZADINE 100MG INJECTION is administered?

    Ans :AZADINE 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of thighs, arms or abdomen.

    Ques 8: How to control nausea caused due to AZADINE 100MG INJECTION?

    Ans :Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with AZADINE 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

    Overview

    Denoci 120 mg Injection is a prescription medication that contains denosumab 120 mg, a monoclonal antibody used to treat osteoporosis and other bone-related conditions. It is commonly prescribed to postmenopausal women and men who are at high risk of bone fractures due to weakened bones.

    Denoci works by blocking a protein called RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand), which is involved in the breakdown of bone. By inhibiting this protein, Denoci helps to reduce bone loss, increase bone density, and strengthen bones. It is also used to prevent bone thinning in patients receiving certain cancer treatments.

    Denoci 120 mg is administered as a subcutaneous injection once every six months by a healthcare professional, and calcium and vitamin D supplements are usually recommended during the course of treatment to support bone health.

    Denoci 120 mg Injection may cause side effects like back, joint, or muscle pain, and pain in the arms or legs. Some people may have high cholesterol or urinary infections. Serious but less common effects include low blood calcium (hypocalcemia), infections, skin rashes, jaw bone issues (osteonecrosis), or rare thigh bone fractures. Inform your doctor about any unusual symptoms or if you have low calcium, kidney problems, or dental concerns. Taking calcium and vitamin D supplements and regular check-ups can help manage side effects.


    Usage

    1. Treats and prevents bone loss in various conditions.

    2. Used for osteoporosis in postmenopausal women at high risk of fractures.

    3. Helps men with osteoporosis who are at increased risk of bone fractures.

    4. Prevents bone loss due to hormone-deprivation therapy in men with prostate cancer.

    5. Reduces bone loss caused by aromatase inhibitor therapy in women with breast cancer

    6.Helps increase bone mass in individuals at risk of fractures due to other medical conditions or treatments.

    Pharmacological Effects

    Denoci 120 mg Injection contains denosumab, a monoclonal antibody that works by targeting and inhibiting a protein called RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand). RANKL is essential for the formation, function, and survival of osteoclasts, the cells responsible for breaking down bone. By blocking RANKL, denosumab prevents the activation of osteoclasts, reducing bone resorption (breakdown) and helping to maintain or increase bone density. This mechanism helps strengthen bones and reduce the risk of fractures, particularly in people with osteoporosis or those undergoing cancer treatments that weaken bones.


    Side Effects

    Side Effects of Denoci 120 mg Injection

    Like all medications, Denoci 120 mg Injection may cause side effects. However, not everyone will experience them.

    Serious Side Effects (Seek immediate medical attention):

    • Low blood calcium levels (hypocalcemia) symptoms may include muscle cramps, numbness, or tingling
    • Serious allergic reactions (rash, swelling, breathing trouble)
    • Serious infections such as skin, abdominal, or urinary infections
    • Osteonecrosis of the jaw (jaw bone damage), especially after dental procedures
    • Atypical femur fractures (unusual thigh bone fractures)
    • It is important to inform your doctor about any unusual symptoms and to maintain adequate calcium and vitamin D intake during treatment.

    Common Side Effects (Usually mild and temporary):

    • Urinary tract infections
    • High cholesterol levels
    • Pain in arms or legs
    • Back pain
    • Joint or back pain

    Dosage

    The recommended dosage of Denoci 120 mg Injection is one injection (120 mg) administered once every six months. It is given as a subcutaneous injection (under the skin) in the upper arm, upper thigh, or abdomen by a healthcare professional.

    Patients are usually advised to take calcium (at least 1000 mg) and vitamin D (at least 400 IU) daily during treatment to help maintain healthy calcium levels and support bone health. Regular follow-up and blood tests may be needed to monitor calcium levels and bone condition.


    Safety Advice for Denoci 120 mg Injection

    Breast Feeding

    Breast Feeding

    Unsafe

    Avoid using this injection while breastfeeding unless advised by your doctor.

    Breast Feeding

    Alcohol

    Consult Your Doctor

    It is advisable to limit alcohol intake, as excessive consumption can weaken bones and increase the risk of side effects.

    Breast Feeding

    Lungs

    Safe

    Use Denoci 120 mg Injection with caution if you have existing lung problems, and immediately inform your doctor if you experience cough, shortness of breath, or chest discomfort during treatment.

    Breast Feeding

    Driving

    Unsafe

    Denoci is unlikely to affect your ability to drive or use machines. However, if you feel dizzy or tired, avoid such activities.

    Breast Feeding

    Pregnancy

    Unsafe

    Denoci is not recommended for use during pregnancy. Inform your doctor if you are pregnant or planning to conceive.

    Storage Advice

  • Store in a refrigerator (2 - 8°C)
  • Do not freeze
  • Keep out of reach of children and pets

  • FAQs about Denoci 120 mg Injection

    Q1. What is Denoci 120 mg Injection used for?

    Denoci is used to treat osteoporosis and bone loss in postmenopausal women and men at high risk of fractures. It is also used in patients receiving hormone therapy for prostate or breast cancer.

    Q2. How is Denoci 120 mg Injection given?

    Denoci is given as a subcutaneous injection (under the skin) once every six months by a healthcare professional.

    Q3. What should I do if I miss a dose?

    If you miss a dose, get it as soon as possible. Future doses should be scheduled every six months from the last injection date.

    Q4. Are there any side effects of Denoci ?

    Yes. Common side effects include back pain, joint pain, high cholesterol, and urinary tract infections. Serious side effects can include low blood calcium levels, infections, and rare jaw or thigh bone problems.

    Q5. Can I take Denoci if I have kidney problems?

    Use with caution in people with kidney issues, as the risk of low calcium levels increases. Your doctor may recommend calcium and vitamin D supplements and regular monitoring.

    Q6. Can I use Denoci during pregnancy or breastfeeding?

    No, Denoci is not recommended during pregnancy or breastfeeding. Inform your doctor if you are pregnant or planning to become pregnant.

    Key Fact Box

    Active ingredient Denosumab
    Pharmacologic class Monoclonal antibody
    Medication category Antiresorptive agent
    Dosage forms Injection
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