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Neuzumab 150mg Injection

prescription

Salt Composition

TRASTUZUMAB

Manufacturer

LUPIN LTD

Origin of Medicine

India

₹6675.00

Inclusive of all taxes

Save ₹ 1668.75 (20%)
MRP:₹8343.75

₹6675.00

    MRP:₹8343.75
Save ₹ 1668.75 (20%)
1 Vial(s)

1 Vial(s)

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Overview & Usage

Overview

Neuzumab 150 mg Injection is a monoclonal antibody that specifically targets the HER2 (human epidermal growth factor receptor 2) protein, which is overexpressed in certain types of cancer cells, particularly HER2-positive breast and gastric cancers.

HER2 is a receptor on the surface of cells that promotes cell growth and division. In cancers where HER2 is overexpressed, the cells grow and divide uncontrollably. Trastuzumab binds to the extracellular domain of the HER2 receptor, blocking its activation. This prevents downstream signaling that promotes cancer cell growth and survival.

Neuzumab 150 mg Injection works by targeting and binding to the HER2 receptor, which helps slow down the growth and replication of cancer cells. While it is effective, it may cause some common side effects such as fever, cough, headache, rash, infections, and sleep disturbances. More serious side effects can include heart failure, allergic reactions, and lung problems. Its use during pregnancy may pose risks to the unborn baby.

Neuzumab 150 mg Injection is given as an IV infusion by a healthcare professional. It may be given weekly or every three weeks, depending on the treatment plan. Pre-medication might be used to reduce infusion reactions. The powder is reconstituted and diluted before use under sterile conditions. Heart function and vital signs are monitored during treatment. Neuzumab should never be self-administered.


Usage

Neuzumab 150 mg Injection is used in the treatment of HER2-positive cancers, specifically:

Breast cancer:

Neuzumab 150 mg Injection is used to treat both early-stage and metastatic HER2-positive breast cancer. It may be given alone or in combination with chemotherapy.

Stomach (gastric) cancer:

It is also used in combination with other cancer medicines to treat advanced HER2-positive gastric or gastroesophageal junction cancer.

Neuzumab 150 mg Injection works by targeting the HER2 receptors on cancer cells, slowing their growth and helping the immune system destroy them. It is only used in patients whose cancer cells test positive for the HER2 protein.

Pharmacological Effects

Neuzumab 150 mg Injection is a biosimilar of trastuzumab that works by targeting a protein called HER2 (Human Epidermal Growth Factor Receptor 2). This protein is present in large amounts on the surface of certain cancer cells. Neuzumab is a monoclonal antibody, meaning it is specially designed to attach itself to the HER2 receptor and block its harmful effects.

Once it binds to HER2, Neuzumab helps stop the cancer cells from growing and surviving. It blocks the signals that encourage cancer growth, directs the immune system to attack and destroy HER2-positive cancer cells, and also reduces the activity of HER2 on the cell surface. Together, these actions slow down tumor growth, lower cancer cell survival, and boost the body’s immune response against the cancer.


Side Effects

Side Effects of Neuzumab 150 mg Injection

Like all medications, Neuzumab 150 mg Injection may cause side effects. However, not everyone will experience them.

Serious Side Effects (Seek immediate medical attention):

  • Heart problems (e.g., heart failure, irregular heartbeat, shortness of breath)
  • Severe allergic reactions (swelling of face/lips, difficulty breathing, itching, or rash)
  • Lung toxicity (trouble breathing, fluid in lungs, cough with fever)
  • Infusion related reactions (severe drop in blood pressure, chest pain, difficulty breathing)
  • Liver function abnormalities (elevated liver enzymes)
  • Low white blood cell count (increased risk of infections)

Common Side Effects (Usually mild and temporary):

  • Fever or chills
  • Nausea or vomiting
  • Headache
  • Cough
  • Diarrhea
  • Weakness or fatigue
  • Rash
  • Body pain or joint pain
  • Trouble sleeping
  • Injection site reactions (pain, redness, or swelling)

Dosage

Neuzumab 150 mg (Trastuzumab) is given as an intravenous (IV) infusion by a qualified healthcare professional experienced in cancer care. The treatment starts with a loading dose of 8 mg/kg, which is infused slowly over about 90 minutes. During and after this infusion, patients are carefully monitored for any possible reactions.

After the loading dose, patients receive a maintenance dose of 6 mg/kg once every 3 weeks (21-day cycle). This dose is usually given over 30 to 90 minutes, depending on how well the patient tolerates the infusion.

The dosage is calculated based on the patient’s actual body weight. Neuzumab should never be given as a rapid or bolus injection. If serious infusion reactions or heart-related problems occur, the doctor may adjust the dose. It is important to always follow the oncologist’s instructions and the hospital’s treatment guidelines.


Safety Advice For Neuzumab 150 mg Injection

Breast Feeding

Breast Feeding

Unsafe

This medicine may pass into breast milk, so breastfeeding is not advised while on Neuzumab. Talk to your doctor before starting or stopping breastfeeding

Breast Feeding

Alcohol

Consult Your Doctor

Drinking alcohol while receiving Neuzumab may increase drowsiness or side effects. Speak to your doctor about safe alcohol use during treatment.

Breast Feeding

Lungs

Consult Your Doctor

Neuzumab should be avoided in people with serious lung problems or those requiring oxygen support. Inform your doctor if you experience any breathing difficulties.

Breast Feeding

Driving

Unsafe

If you feel tired, dizzy, or unwell after receiving Neuzumab, avoid driving until you feel better.

Breast Feeding

Pregnancy

Unsafe

Neuzumab 150 mg Injection should not be used during pregnancy. Women who could become pregnant must use effective birth control during treatment and for at least 7 months after the last dose. If you become pregnant during treatment, inform your doctor right away.

Storage Advice

  • Store in a refrigerator (2 - 8°C)
  • Do not freeze
  • Keep out of reach of children and pets

  • FAQs about Neuzumab 150 mg Injection

    Q1. How does Neuzumab 150mg Solution for Infusion work differently from Chemotherapy?

    Neuzumab 150 mg (Trastuzumab) works differently from chemotherapy by specifically targeting cancer cells that overexpress the HER2 protein, which is found in certain types of breast and gastric cancers. Unlike chemotherapy, which attacks all rapidly dividing cells (including healthy ones), Neuzumab binds to the HER2 receptors on cancer cells to block growth signals and activate the immune system to destroy these cells. This targeted approach makes Neuzumab more precise, often resulting in fewer side effects compared to traditional chemotherapy.

    Q2. Do the side effects of Neuzumab 150mg Injection last for a long time?

    The side effects of Neuzumab 150 mg Injection (Trastuzumab) usually occur while the medicine is active in the body and often improve after treatment is completed. However, some side effects especially those related to the heart or lungs may last longer or appear even after stopping the medicine. Common side effects like fever, chills, or nausea are generally short-term, while serious effects such as heart function problems may require long-term monitoring. It's important to report any lasting or new symptoms to your doctor, even after treatment ends, for proper follow-up and care.

    Q3.What should I do if I miss a dose of Trastuzumab?

    If you miss a dose of Trastuzumab (Neuzumab 150 mg), contact your doctor or healthcare provider as soon as possible. They will decide when and how to give the missed dose, based on your treatment schedule. Do not try to take the missed dose on your own or double up on the next dose, as this may increase the risk of side effects. Always follow your doctor’s instructions to keep your treatment on track safely.p>

    Q4. Can Trastuzumab interact with food or drinks?

    Trastuzumab (Neuzumab) does not have any known food or drink interactions, so you can continue with your normal diet unless your doctor advises otherwise. However, it is best to limit alcohol, as it may increase fatigue or nausea, and avoid too much caffeine, which can lead to palpitations or trouble sleeping. Staying well-hydrated is also important, especially if you are receiving chemotherapy. Always follow the dietary advice given by your doctor during treatment to ensure the best care.

    Q5. Are there any drug interactions with Trastuzumab?

    Trastuzumab (Neuzumab 150 mg) has a low risk of drug interactions but should still be used with caution. When combined with chemotherapy (like paclitaxel or carboplatin), the risk of heart issues or low white blood cells may increase. It may also affect heart medicines and immune responses to vaccines. Always inform your doctor about all medicines and supplements you are taking.

    Q6. Can Neuzumab affect my heart?

    Yes, Neuzumab may cause heart problems in some patients. Your doctor will monitor your heart function before and during treatment. Report symptoms like shortness of breath, swelling in the legs, or chest pain immediately. Yes, Bevacizumab can interact with certain medicines, including paclitaxel and carboplatin. To avoid possible interactions, always inform your doctor about all the medications you are taking.

    Key Fact Box

    Active ingredient Trastuzumab
    Pharmacologic class Recombinant IgG1 monoclonal antibody
    Medication category ANTI NEOPLASTICS
    Dosage forms Injection

    DOSAGE

    Frequently Asked Questions

    Azadine 100mg Injection contains Azacitidine which belongs to the group of medicines called Anticancer agents. It is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Azadine 100mg Injection is typically used in adults who cannot undergo stem cell transplantation. It may be also used to treat other conditions, as determined by the doctor.

    Azadine Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

    You must inform your doctor before taking any vaccination while on treatment with this medicine. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

    Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.

    MEDICINAL USE OF AZADINE 100MG INJECTION

    Azadine 100mg Injection is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    It is used to treat:

    • All sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow)
    • Chronic myelomonocytic leukemia (CMML; blood cancer of monocytes)
    • Acute myeloid leukemia (AML; blood cancer of WBC)
    SIDE EFFECTS OF AZADINE 100MG INJECTION

    Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

    • Low RBC count causing anemia, tiredness and pale skin
    • Increased infections, lung infections (pneumonia), fever and chills
    • Increased bleeding tendency due to low blood platelet counts
    • Nausea, vomiting
    • Diarrhea, constipation, loss of appetite, stomach pain
    • Tiredness, weakness
    • Injection site reactions (such as pain, redness and swelling or lump formation)
    • Joint pain, muscle pain, skin rashes with redness and itching
    • Sore nose and throat, cold sores, sinnusitis
    • Headache, dizziness
    • Trouble sleeping (insomnia)
    • Nosebleeds, bleeding gums
    • Weight loss
    • Urinary tract infections
    • Ulcers of mouth or tongue
    • High or low blood pressure
    • Anxiety, confusion
    • Hair loss, dehydration
    • Oral fungal infection
    • Sleepiness
    • Fluid around the lungs or heart
    DOSAGE OF AZADINE 100MG INJECTION
    • The dose of Azacitidine is determined by the patient's height, weight, and general condition. It is given under the skin of your thigh, stomach, or upper arm.
    • Minimum of 4 to 6 cycles; may continue treatment if the patient continues to benefit.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of a missed dose is very low.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

    Ques 1: What is the use of AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Ques 2: How does AZADINE 100MG INJECTION works?

    Ans :AZADINE 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    Ques 3: Can I take AZADINE 100MG INJECTION during breastfeeding?

    Ans :No. AZADINE 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.

    Ques 4: Can AZADINE 100MG INJECTION increase the risk of infections?

    Ans :AZADINE 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving AZADINE 100MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.

    Ques 5: Can the use of AZADINE 100MG INJECTION make me feel tired?

    Ans :Yes. AZADINE 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anemic. Consult your doctor if you experience tiredness after receiving AZADINE 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.

    Ques 6: Can I drive a car after receiving AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by AZADINE 100MG INJECTION.

    Ques 7: How AZADINE 100MG INJECTION is administered?

    Ans :AZADINE 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of thighs, arms or abdomen.

    Ques 8: How to control nausea caused due to AZADINE 100MG INJECTION?

    Ans :Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with AZADINE 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

    Overview

    Neuzumab 150 mg Injection is a monoclonal antibody that specifically targets the HER2 (human epidermal growth factor receptor 2) protein, which is overexpressed in certain types of cancer cells, particularly HER2-positive breast and gastric cancers.

    HER2 is a receptor on the surface of cells that promotes cell growth and division. In cancers where HER2 is overexpressed, the cells grow and divide uncontrollably. Trastuzumab binds to the extracellular domain of the HER2 receptor, blocking its activation. This prevents downstream signaling that promotes cancer cell growth and survival.

    Neuzumab 150 mg Injection works by targeting and binding to the HER2 receptor, which helps slow down the growth and replication of cancer cells. While it is effective, it may cause some common side effects such as fever, cough, headache, rash, infections, and sleep disturbances. More serious side effects can include heart failure, allergic reactions, and lung problems. Its use during pregnancy may pose risks to the unborn baby.

    Neuzumab 150 mg Injection is given as an IV infusion by a healthcare professional. It may be given weekly or every three weeks, depending on the treatment plan. Pre-medication might be used to reduce infusion reactions. The powder is reconstituted and diluted before use under sterile conditions. Heart function and vital signs are monitored during treatment. Neuzumab should never be self-administered.


    Usage

    Neuzumab 150 mg Injection is used in the treatment of HER2-positive cancers, specifically:

    Breast cancer:

    Neuzumab 150 mg Injection is used to treat both early-stage and metastatic HER2-positive breast cancer. It may be given alone or in combination with chemotherapy.

    Stomach (gastric) cancer:

    It is also used in combination with other cancer medicines to treat advanced HER2-positive gastric or gastroesophageal junction cancer.

    Neuzumab 150 mg Injection works by targeting the HER2 receptors on cancer cells, slowing their growth and helping the immune system destroy them. It is only used in patients whose cancer cells test positive for the HER2 protein.

    Pharmacological Effects

    Neuzumab 150 mg Injection is a biosimilar of trastuzumab that works by targeting a protein called HER2 (Human Epidermal Growth Factor Receptor 2). This protein is present in large amounts on the surface of certain cancer cells. Neuzumab is a monoclonal antibody, meaning it is specially designed to attach itself to the HER2 receptor and block its harmful effects.

    Once it binds to HER2, Neuzumab helps stop the cancer cells from growing and surviving. It blocks the signals that encourage cancer growth, directs the immune system to attack and destroy HER2-positive cancer cells, and also reduces the activity of HER2 on the cell surface. Together, these actions slow down tumor growth, lower cancer cell survival, and boost the body’s immune response against the cancer.


    Side Effects

    Side Effects of Neuzumab 150 mg Injection

    Like all medications, Neuzumab 150 mg Injection may cause side effects. However, not everyone will experience them.

    Serious Side Effects (Seek immediate medical attention):

    • Heart problems (e.g., heart failure, irregular heartbeat, shortness of breath)
    • Severe allergic reactions (swelling of face/lips, difficulty breathing, itching, or rash)
    • Lung toxicity (trouble breathing, fluid in lungs, cough with fever)
    • Infusion related reactions (severe drop in blood pressure, chest pain, difficulty breathing)
    • Liver function abnormalities (elevated liver enzymes)
    • Low white blood cell count (increased risk of infections)

    Common Side Effects (Usually mild and temporary):

    • Fever or chills
    • Nausea or vomiting
    • Headache
    • Cough
    • Diarrhea
    • Weakness or fatigue
    • Rash
    • Body pain or joint pain
    • Trouble sleeping
    • Injection site reactions (pain, redness, or swelling)

    Dosage

    Neuzumab 150 mg (Trastuzumab) is given as an intravenous (IV) infusion by a qualified healthcare professional experienced in cancer care. The treatment starts with a loading dose of 8 mg/kg, which is infused slowly over about 90 minutes. During and after this infusion, patients are carefully monitored for any possible reactions.

    After the loading dose, patients receive a maintenance dose of 6 mg/kg once every 3 weeks (21-day cycle). This dose is usually given over 30 to 90 minutes, depending on how well the patient tolerates the infusion.

    The dosage is calculated based on the patient’s actual body weight. Neuzumab should never be given as a rapid or bolus injection. If serious infusion reactions or heart-related problems occur, the doctor may adjust the dose. It is important to always follow the oncologist’s instructions and the hospital’s treatment guidelines.


    Safety Advice For Neuzumab 150 mg Injection

    Breast Feeding

    Breast Feeding

    Unsafe

    This medicine may pass into breast milk, so breastfeeding is not advised while on Neuzumab. Talk to your doctor before starting or stopping breastfeeding

    Breast Feeding

    Alcohol

    Consult Your Doctor

    Drinking alcohol while receiving Neuzumab may increase drowsiness or side effects. Speak to your doctor about safe alcohol use during treatment.

    Breast Feeding

    Lungs

    Consult Your Doctor

    Neuzumab should be avoided in people with serious lung problems or those requiring oxygen support. Inform your doctor if you experience any breathing difficulties.

    Breast Feeding

    Driving

    Unsafe

    If you feel tired, dizzy, or unwell after receiving Neuzumab, avoid driving until you feel better.

    Breast Feeding

    Pregnancy

    Unsafe

    Neuzumab 150 mg Injection should not be used during pregnancy. Women who could become pregnant must use effective birth control during treatment and for at least 7 months after the last dose. If you become pregnant during treatment, inform your doctor right away.

    Storage Advice

  • Store in a refrigerator (2 - 8°C)
  • Do not freeze
  • Keep out of reach of children and pets

  • FAQs about Neuzumab 150 mg Injection

    Q1. How does Neuzumab 150mg Solution for Infusion work differently from Chemotherapy?

    Neuzumab 150 mg (Trastuzumab) works differently from chemotherapy by specifically targeting cancer cells that overexpress the HER2 protein, which is found in certain types of breast and gastric cancers. Unlike chemotherapy, which attacks all rapidly dividing cells (including healthy ones), Neuzumab binds to the HER2 receptors on cancer cells to block growth signals and activate the immune system to destroy these cells. This targeted approach makes Neuzumab more precise, often resulting in fewer side effects compared to traditional chemotherapy.

    Q2. Do the side effects of Neuzumab 150mg Injection last for a long time?

    The side effects of Neuzumab 150 mg Injection (Trastuzumab) usually occur while the medicine is active in the body and often improve after treatment is completed. However, some side effects especially those related to the heart or lungs may last longer or appear even after stopping the medicine. Common side effects like fever, chills, or nausea are generally short-term, while serious effects such as heart function problems may require long-term monitoring. It's important to report any lasting or new symptoms to your doctor, even after treatment ends, for proper follow-up and care.

    Q3.What should I do if I miss a dose of Trastuzumab?

    If you miss a dose of Trastuzumab (Neuzumab 150 mg), contact your doctor or healthcare provider as soon as possible. They will decide when and how to give the missed dose, based on your treatment schedule. Do not try to take the missed dose on your own or double up on the next dose, as this may increase the risk of side effects. Always follow your doctor’s instructions to keep your treatment on track safely.p>

    Q4. Can Trastuzumab interact with food or drinks?

    Trastuzumab (Neuzumab) does not have any known food or drink interactions, so you can continue with your normal diet unless your doctor advises otherwise. However, it is best to limit alcohol, as it may increase fatigue or nausea, and avoid too much caffeine, which can lead to palpitations or trouble sleeping. Staying well-hydrated is also important, especially if you are receiving chemotherapy. Always follow the dietary advice given by your doctor during treatment to ensure the best care.

    Q5. Are there any drug interactions with Trastuzumab?

    Trastuzumab (Neuzumab 150 mg) has a low risk of drug interactions but should still be used with caution. When combined with chemotherapy (like paclitaxel or carboplatin), the risk of heart issues or low white blood cells may increase. It may also affect heart medicines and immune responses to vaccines. Always inform your doctor about all medicines and supplements you are taking.

    Q6. Can Neuzumab affect my heart?

    Yes, Neuzumab may cause heart problems in some patients. Your doctor will monitor your heart function before and during treatment. Report symptoms like shortness of breath, swelling in the legs, or chest pain immediately. Yes, Bevacizumab can interact with certain medicines, including paclitaxel and carboplatin. To avoid possible interactions, always inform your doctor about all the medications you are taking.

    Key Fact Box

    Active ingredient Trastuzumab
    Pharmacologic class Recombinant IgG1 monoclonal antibody
    Medication category ANTI NEOPLASTICS
    Dosage forms Injection
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